Fuafuaina mea mata fou

Molecular self-assembly

--se kemisi lanumeamata tuaoi e aunoa ma le motusia o sootaga ma toe fesootai

O le mataupu faavae o le molecular self-assembly:

1. Fa'apei e tosina mai fa'apei - fa'aoso mea fa'apena e fa'apotopoto ma fa'atulaga e le tasi le isi, ma mea fa'atasi e fa'atosina ai le tasi ma le isi.

2. O le malosi aupito maualalo—fa'agaioiga o mea ma amioga mole mole o le a aga'i atu i le tulaga sili ona mautu. O se auala mo kulupu mole e fa'atulagaina i fausaga maualuluga.

Molecular self-assembly-designability, o le CP structure i le va o molelaʻau e mafai ona faʻaleleia atili le gaioiga o meaola:

1. O mole taʻitasi e iai lona fausaga faʻapitoa ma mea faʻapitoa, ma e faigata ona maua le synergy ma togafitiga saʻo e faʻavae i luga o le faʻafefiloi saoloto i le tulaga faʻavae.

2. O loʻo i ai pea le tele o molelaʻau e sili ona lelei gaioiga faʻaola e matua faʻatapulaʻaina lo latou faʻaogaina ma le faʻaogaina ona o latou uiga le lelei.

3. O vaila'au fa'aleaganu'u a Saina e fa'apitoa e uiga i "le tupu, faife'au ma fesoasoani", nai lo le fa'atosina o le tele o le lelei.

Suramolecular fausaga suiga ma optimization auiliiliga faagasologa faataitaiga:

1. Su'esu'ega maualuga fa'akomepiuta mo le su'esu'eina vave o mea muamua mai le Cambridge Crystal Data Center.

2. Fa'aaogā a'oa'oga fa'agaoioiga e su'esu'e ai le fa'atulagaga sili ma le fa'apotopotoga fa'apitoa e fa'atatau i malosiaga fa'atasi, ma iloa ai po'o fea ituaiga supramolecular e fa'atupuina.

3. I le iloiloina o tulaga tali atu ma faigata, o le fausaga supramolecular na sili ona lelei.

4. Fuafuaga o meatotino eseese o supramoleleti, e aofia ai le eletise, opitika ma thermodynamic meatotino.

5. Fuafuaga o mea fa'apitoa e pei ole alaleo mole ma alaleo malosi.

6.Through molecular docking technology, o le fesoʻotaʻiga nofoaga i le va o supramolecular mata meamata ma polotini taulaʻi ua valoia, ma le faiga fegalegaleaiga i le va o molelaʻau faʻamatalaina loloto.

Supramolecular eutectic/Ionic masima tekinolosi

Fa'amatalaga fa'apitoa: muamua a le alamanuia, su'esu'eina vaega sili ona lelei CP o vaega fa'agaioiga mo le fa'amalosia eutectic

Tulaga lelei: faʻaitiitia le ita, faʻaleleia le solubility, faʻaleleia galuega, faʻaleleia le faʻaogaina, faʻaleleia le mautu

Faataitaiga o mea aoga: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

O mea faʻapitoa faʻapitoa e maua mai le faʻamaumauga o mea teuteu mataʻutia, pe a maeʻa suʻega faʻamaonia e pei o le quantum chemical simulation, suʻesuʻega maualuga, Gaussian optimization, KingDraw, MestReNova, FTIR, ma le NMR, o oloa na maua e sili ona lelei le tolu-dimensional fausaga tioata, lelei mautu, maualuga mama, itiiti le mama. E mafai ona foia lelei le faʻaogaina o tiga o mea aoga i meaʻai, vailaʻau ma mea teuteu, ma faʻaleleia le bioavailability ma le saogalemu o mea aoga.

Fa'atekonolosi e fa'aosoina ai gaioiga sili

vaega fa'ainisinia: Muamua a le alamanuia, o le tu'ufa'atasiga o tekonolosi fa'apipi'i mole mole ma so'o fa'alenatura supramolecular, fa'aleleia lelei o mea fa'ato'aga.

A'oa'oga: Fa'atatau i le fa'aputuina, o le fa'asili e fa'aopoopoina i le 5 taimi pe a fa'atusatusa i le ava malosi, ma le fa'aputuina o vai e 20 taimi; leai se tete'a, fa'aitiitiga tau, mea e fa'aolaina ai le fa'aosoina Fa'ata'ita'iga: olive (oleuropein, hydroxytyrosol), rhodiola, vaila'au Phyloporus, lili vai pa'epa'e, micrococcus

Natural deep eutectic solvent (NaDES): Na maua muamua e saienitisi i le auiliiliga o metabolomics laau. I le taimi o le tuputupu aʻe o laʻau (germination, cryopreservation), o sela o le a faʻafuaseʻi ona fausia se vai e sili ona viscous e tutoatasi mai vai ma lipids, e tutusa ma le faʻafefiloi o eutectics.

Faʻavae i luga o tekinolosi faʻaonaponei lanumeamata vavae ese, tekinolosi membrane tuʻufaʻatasia, faʻapipiʻiina e le ultrasonic / microwave faʻaleleia tekinolosi e ausia ai le maualalo o le vevela, faʻamoemoeina, maualuga le maualuga, maualuga ma le lanu meamata faʻapipiʻiina o vaega malosi. O le suramolecular solvent filifilia o loʻo i ai le faʻatinoina o le faʻatinoga ma le faʻaleleia atili o le solubility o mea aoga, faʻapea foʻi ma le faʻaogaina lelei e mafai ona faʻateleina i le 20 taimi.

Supramolecular synergistic penetration technology

Fa'amatalaga fa'atekinisi: O le alamanuia muamua, e ala i le so'u so'o supramolecular synergistically fa'alauiloa le ulu atu o macromolecules/vai-soluble/faigata ona mitiia mea'ai.

Tulaga faʻapitoa: faʻaleleia le mautu, le faʻaleagaina ma le faʻaleleia atili o le ulu, faʻaogaina o le synergistic, faʻatamaoaigaina faʻatonu i le dermis, ma le bioavailability faʻateleina i le 5-7 taimi Faʻataʻitaʻiga o mea: collagen, Bosein, blue copper peptide, hexapeptide, compound peptide , β-glucan.

Talu ai o le mamafa mole mole o le peptide e lapopoa tele pe a faʻatusatusa i isi mea aoga, o le paʻu o le paʻu e laʻititi lava. O nisi o auala e faʻaleleia atili ai e manaʻomia e faʻaleleia ai le faʻaogaina o le faʻaogaina o le peptide, ina ia maua ai le maualalo o le faʻaogaina ma le maualuga o le aoga, ma ausia ai le lelei o le anti-matua.

I le tali atu i le tulaga tiga alamanuia o le le lelei o le ulu, hydrophilicity maualuga ma le maualalo o le bioavailability o macromolecules masani, o le JUNAS Time Particle products synthesis e ala i quantum chemistry fesoasoani, e mafai ona oʻo saʻo atu i le epidermis ma dermis o le paʻu e ala i trans-cellular, intercellular ma follicular afu ductchannels. E aunoa ma le faʻaleagaina o le fausaga o le paʻu.O le bioavailability o le oloa e faʻateleina i le 5 taimi, e aofia ai le sili atu i le 45% i le dermis, e aunoa ma le faʻaleagaina o le fausaga o le paʻu.

Supramolecular biocatalysis tekinolosi

Bioenzyme-directed catalysis: suramolecular solvents e faʻaaogaina e fai ma mea e faʻaleleia ai le gaioiga o le enzyme, faʻaleleia le filifilia o chiral, ma ausia le mama maualuga.

Inisinia fennel green fermentation: filifili laʻau faʻapitoa, faʻaleleia mea o loʻo i totonu o mea aoga, faʻasologa o le anhydrous, faʻaleleia atili le aoga.

Fa'aliliuina le micellar fermentation technology: su'esu'eina uiga fa'aleaga, fa'afefeteina le suau'u fualaau faisua, sili atu a'afiaga, fa'aleleia le lagona o le pa'u ma fa'aleleia le fa'afefe.

Faʻavae i luga o le recombinant gene technology, tasi-step gene cloning technology and high-density bioenzyme catalytic technology, genetically engineered bacteria o loʻo faʻaaogaina e avea ma pusa faʻamalosi e iloa ai le gaosiga tele o mea faʻamalosi:

I lalo o le supramolecular solvent system, o le enzyme o loʻo faʻaalia ai le maualuga o le gaioiga, filifili ma le mautu, faʻaogaina maualuga o meafaitino mataʻutia, faʻaitiitia le faʻaleagaina i le gaosiga o le gaosiga, tulaga malie o tali, maualuga le saogalemu ma le gaosiga o gaioiga.

Fa'atekonolosi fa'afefete micelle:

suau'u fa'anatura filifilia ma uiga Saina lP ua fuafuaina fa'afuase'i e maua ai surfactants i lalo o le gaioiga a genetically engineered bacteria.lt ua fa'apotopotoina e avea ma ave o le anti-micellar fusi e iloa ai le afifi anti-micellar afifi o vai-soluble mea aoga e ausia scenarios mauoa talosaga, aafiaga sili paʻu, ma le aoga ofoofogia, poto masani, ma taua taua.

Supramolecular microencapsulation tekinolosi

Fa'amatalaga fa'atekinisi: liposome encapsulation, fa'amatu'u fa'atatau o sela dermal, fa'amatu'u fa'amatu'u o follicle o lauulu, ma fa'amatu'u tali atu o mea fa'ama'i.

Tulaga lelei: Nanoization, tuʻuina atu saʻo, faʻasaʻolotoga tumau, faʻaitiitia le ita, faʻaleleia le mautu, ma faʻalauteleina le faʻaogaina.

Faataitaiga o mea aoga: astaxanthin, glabridin, vitamini A, blue copper peptide, biotin, ceramide, suauu taua o laau.

Supramolecular microencapsulation tekinolosi e faavae i luga o le liposome, emulsion gaʻo, ionic sua tekinolosi stabilization, dermal cell taulaʻi faatekinolosi tuʻuina atu, lauulu follicle faʻasaʻo tekinolosi faʻasaʻo, ma mea inflammatory tali faʻasaʻolotoga technology.By fatuina ala felauaiga faafoliga, e mafai e le oloa tuuina atu le vaega galue saʻo. O lo'o i ai le maualuga o le transdermal absorption rate, umi taimi e nofo ai ma lelei le mautu i le nofoaga fa'atatau i le pa'u. O lo'o iai fo'i le tau maualalo ma le maualuga o le fa'aoga lelei i le tulaga o mea teuteu, mea'ai aoga ma vaila'au.

Tekinolosi fa'apipi'i fa'apitoa a le peptide

Fa'amatalaga fa'atekinisi: muamua a le alamanuia, fa'atonu fa'atonuga o le fa'atulagaga tele o filifili amino acid ma polypeptides, peptides pu'upu'u fa'atasi, polypeptides supramolecular.

Faʻatonuga faʻapitoa: Faʻaleleia le amphiphility, faʻaleleia le mautu ma le vevela, faʻaitiitia le oona ma le faʻalavelave puipuia, faʻaleleia le faʻaogaina, ma faʻatasi

Faataitaiga o mea aoga: supramolecular carnosine, yeast protein peptide

O le faʻapipiʻiina e le tagata lava ia o polotini ma peptide e le gata o loʻo i ai i le olaga atoa, ae o se mea sili ona lelei mo le tino o le tagata, ma o se tasi foi o auala aoga mo le faʻapipiʻiina o mea faʻaoga nano-biological. O le peptide lava-potopotoga faagasologa o se faagasologa o le faapotopotoga hierarchical, ma le "polar amino acid sipa fausaga" o se ituaiga fou o super-lua fausaga, lea e conducive i le faapotopotoga hierarchical o peptides e fausia ai aggregates faatonuina.

Fa'atonu tulafono faatonutonu o le tele o peptides pupuu e mafai ona ausia e ala i le suia o le hydrophobicity ma filifili filifili lala o totoe hydrophobic.

Faʻavae i luga ole Shinehigh Innovation's unique ProteinDataBank (PDB) database, tuʻufaʻatasia ma suʻesuʻega faʻataʻitaʻiga, molecular dynamics ma quantum chemistry calculations e iloilo ai le fausaga o mole mole peptide, ona fetaui lea ma le maualuga-throughput self-assembly molecules. le gafatia o le mole e faʻapipiʻi e le tagata lava ia. Ia iloa le faʻatonuga faʻatonutonu o peptides. O le peptide faʻapipiʻiina e le tagata lava ia e sili ona lelei le amphiphilicity ma le faʻatusa, lea e faʻaleleia atili ai le mautu o le peptide, gafatia transdermal ma le bioavailability.